Автоматизированная система управления газотурбинной электростанцией с закрытой распределительной установкой

Проектирование автоматизированной системы управления газотурбинной электростанцией с закрытой распределительной установкой позволит увеличить производительность, экономичность и безопасность в сравнение с имеющейся.Design of an automated control system for a gas turbine power plant with a closed distribution system. It will increase productivity, efficiency and safety in comparison with the existing one

Исследование изотопной селективности процесса кристаллизации NaCl из водного раствора, находящегося в магнитном поле

Объектом исследования являются кристаллы NaCl, выращенные под воздействием постоянного магнитного поля из водного раствора. В данной работе приведены теоретическое обоснование и результаты исследований по изменению изотопного эффекта в постоянном магнитном поле при кристаллизации NaCl из водных растворов.The object of study are NaCl crystals grown under the influence of a constant magnetic field from an aqueous solution. This paper presents the theoretical justification and research results on the change in the isotope effect in a constant magnetic field during crystallization of NaCl from aqueous solutions

HIF-1α-Deficiency in Myeloid Cells Leads to a Disturbed Accumulation of Myeloid Derived Suppressor Cells (MDSC) During Pregnancy and to an Increased Abortion Rate in Mice

Abortions are the most important reason for unintentional childlessness. During pregnancy, maternal immune cells are in close contact to cells of the semi-allogeneic fetus. Dysregulation of the maternal immune system leading to defective adaptation to pregnancy often plays a role in pathogenesis of abortions. Myeloid-derived suppressor cells (MDSC) are myeloid cells that suppress functions of other immune cells, especially T-cells, thereby negatively affecting diseases such as cancer, sepsis or trauma. They seem, however, also necessary for maintenance of maternal-fetal tolerance. Mechanisms regulating MDSC expansion and function during pregnancy are only incompletely understood. In tumor environment, hypoxia is crucial for MDSC accumulation and activation. Hypoxia is also important for early placenta and embryo development. Effects of hypoxia are mediated through hypoxia-inducible factor 1α (HIF-1α). In the present study we aimed to examine the role of HIF-1α in myeloid cells for MDSC accumulation and MDSC function during pregnancy and for pregnancy outcome. We therefore used a mouse model with targeted deletion of HIF-1α in myeloid cells (myeloid HIF-KO) and analyzed blood, spleens and uteri of pregnant mice at gestational day E 10.5 in comparison to non-pregnant animals and wildtype (WT) animals. Further we analyzed pregnancy success by determining rates of failed implantation and abortion in WT and myeloid HIF-KO animals. We found that myeloid HIF-KO in mice led to an abrogated MDSC accumulation in the pregnant uterus and to impaired suppressive activity of MDSC. While expression of chemokine receptors and integrins on MDSC was not affected by HIF-1α, myeloid HIF-KO led to increased apoptosis rates of MDSC in the uterus. Myeloid-HIF-KO resulted in increased proportions of non-pregnant animals after positive vaginal plug and increased abortion rates, suggesting that activation of HIF-1α dependent pathways in MDSC are important for maintenance of pregnancy

Система генерации отчетов САПР бортового программного обеспечения космических аппаратов

Целью работы является проектирование и реализация системы генерации отчетов в САПР БПО. В ходе работы разработана система, призванная автоматизировать создание отчетов по данным, которыми оперирует САПР БПО. В частности, система позволяет генерировать отчеты по ресурсам, отчет-Д по отображению формата кадров телеметрической информации и документ "Исходные данные на изделие". В отчетах заполняются таблицы по использованию аппаратных ресурсов спутника бортовым программным обеспечением. Отчеты формируются в качестве документов Microsoft Word и Excel с требуемым форматированием.The aim of the work is to design and implement the report generating system in CAD BS. As the result of the work, the system that automates the creation of reports was developed. Particularly, the system allows to generate resource reports, “Report-D” that shows formats of the telemetry data and the document “Satellite Source Data”. The system fills the tables describing satellite hardware resource distribution by on-board software. The reports are formed as Microsoft Word and Excel documents with required formatting

Влияние геометрии вертикальных ребер на производительность емкостей для десублимации газообразного UF6

Объектом исследования является вертикальная погружная емкость с вертикальным оребрением. В процессе исследования проводился расчет зависимостей средней производительности емкостей объемом от 1 до 4 кубометров с вертикальным оребрением от длины и ширины вертикальных ребер. Для данных емкостей были определены оптимальные значения ширины и длины вертикальных ребер.The object of study is a vertical immersion tank with vertical fins. In the course of the study, the dependences of the average productivity of containers with a volume of 1 to 4 cubic meters with vertical ribbing on the length and width of vertical ribs were calculated. For these containers, the optimal values of the width and length of the vertical ribs were determined

Long-Term Effects of Inhaled Budesonide for Bronchopulmonary Dysplasia

Peer reviewe

Best practices for the diagnosis and evaluation of infants with robin sequence:a clinical consensus report

Importance: Robin sequence (RS) is a congenital condition characterized by micrognathia, glossoptosis, and upper airway obstruction. Currently, no consensus exists regarding the diagnosis and evaluation of children with RS. An international, multidisciplinary consensus group was formed to begin to overcome this limitation. Objective: To report a consensus-derived set of best practices for the diagnosis and evaluation of infants with RS as a starting point for defining standards and management. Evidence Review: Based on a literature review and expert opinion, a clinical consensus report was generated. Findings: Because RS can occur as an isolated condition or as part of a syndrome or multiple-anomaly disorder, the diagnostic process for each newborn may differ. Micrognathia is hypothesized as the initiating event, but the diagnosis of micrognathia is subjective. Glossoptosis and upper airway compromise complete the primary characteristics of RS. It can be difficult to judge the severity of tongue base airway obstruction, and the possibility of multilevel obstruction exists. The initial assessment of the clinical features and severity of respiratory distress is important and has practical implications. Signs of upper airway obstruction can be intermittent and are more likely to be present when the infant is asleep. Therefore, sleep studies are recommended. Feeding problems are common and may be exacerbated by the presence of a cleft palate. The clinical features and their severity can vary widely and ultimately dictate the required investigations and treatments. Conclusions and Relevance: Agreed-on recommendations for the initial evaluation of RS and clinical descriptors are provided in this consensus report. Researchers and clinicians will ideally use uniform definitions and comparable assessments. Prospective studies and the standard application of validated assessments are needed to build an evidence base guiding standards of care for infants and children with RS